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An efficient palladium-catalyzed regioselective 5-exo aminotrifluoromethoxylation of alkenes has been established herein,which provides a practical route towards the synthesis of OCF3-containing pyrrolidines.tert-Butyloxycarbonyl (Boc) as an amino protecting group plays a significant role in both the chemo-and regioselectivities.In addition,preliminary mechanistic studies reveal that the amino protecting group of substrates and the counter anion of palladium catalyst play critical roles in reaction efficiency presumably due to an isomerization of alkyl-Pd(Ⅱ) intermediates.Moreover,the asymmetric 5-exo aminotrifluoromethoxylation reaction has also been achieved by introducing a sterically bulky pyridinyl-oxazoline ligand.