【摘 要】
：
Growing evidence suggests that there are similar pathological mechanisms and closely related pathogenic risk factors for inflammatory bowel disease (IBD) and Parkinson\'s disease (PD). However, the epidemiological features of these two diseases are diff
【机 构】
：
Department of Neurology,Jiangxi Provincial People’s Hospital,Affiliated People’s Hospital of Nanchan
论文部分内容阅读
Growing evidence suggests that there are similar pathological mechanisms and closely related pathogenic risk factors for inflammatory bowel disease (IBD) and Parkinson\'s disease (PD). However, the epidemiological features of these two diseases are different. This review systematically evaluated the relationship between inflammatory bowel diseases and Parkinson\'s disease risk. We searched PubMed, Embase, and Cochrane databases to retrieve observational studies of IBD and PD published from inception to October 2019. Nine observational studies, involving 12,177,520 patients, were included in the final analysis. None of the studies had Newcastle–Ottawa Scale scores that suggested a high risk of bias. After adjusting for confounders and excluding heterogeneous studies, the overall risk of PD was significantly higher in IBD patients than in the general population (adjusted risk ratio [RR] = 1.24, 95％ confidence interval [CI]: 1.15–1.34, P < 0.001). A meta-analysis of the temporal relationship revealed that the incidence of IBD was significantly increased before (adjusted hazard ratio [HR] = 1.26, 95％ CI: 1.18–1.35, P < 0.001) and after (adjusted RR = 1.40, 95％ CI: 1.20–1.80, P < 0.001) PD diagnosis. After excluding a heterogeneous study, the pooled risk of PD development in patients with ulcerative colitis (adjusted HR = 1.25, 95％ CI: 1.13–1.38, P < 0.001) or Crohn\'s disease (adjusted HR =1.33, 95％ CI: 1.21–1.45, P 65 years old) IBD patients (adjusted HR = 1.32, 95％ CI: 1.17–1.48) may have a higher risk than younger (≤ 65 years old) patients (adjusted HR = 1.24, 95％ CI: 1.08–1.42). Patients with IBD who were not treated with anti-tumor necrosis factor-α or azathioprine had significantly higher PD risk (adjusted HR = 1.6, 95％ CI: 1.2–2.2). Thus, our meta-analysis indicates a certain correlation between IBD and PD, and suggests that IBD may moderately increase PD risk regardless of sex, especially in patients over 65 years of age. Moreover, early anti-inflammatory therapies for IBD might reduce the risk of developing PD. Our findings suggest an urgent need for an individualized screening strategy for patients with IBD. However, most studies included in this paper were observational, and more randomized controlled trials are needed to confirm the precise association between IBD and PD.
其他文献
Morphological analyses are key outcome assessments for nerve regeneration studies but are historically limited to tissue sections.Novel optical tissue clearing techniques enabling three-dimensional imaging of entire organs at a subcellular resolution have
Autophagy has been shown to play an important role in Parkinson\'s disease.We hypothesized that skin-derived precursor cells exhibit neuroprotective effects in Parkinson\'s disease through affecting autophagy.In this study,6-hydroxydopamine-damaged SH
The mechanism of AD remains uncovered:The current mainstream doctrine in Alzheimer\'s disease (AD) is the amyloid cascade hypothesis. According to this hypothesis, amyloid-β (Aβ) deposition is the main reason for neurofibrillary tangles formation and sy
Severe cerebral ischemia/reperfusion injury has been shown to induce high-level autophagy and neuronal death. Therefore, it is extremely important to search for a target that inhibits autophagy activation. Long non-coding RNA MEG3 participates in autophag
The nervous system is a highly complex organization composed of its basic unit, the neuronal cells, and specialized supporting cells, the glial cells. The main glial cells in the central nervous system (CNS) are astrocytes, microglia and oligodendrocytes.
Mutations that cause protein misfolding are implicated in conditions such as retinitis pigmentosa (RP), Usher Syndrome, and myocilin associated primary open angle glaucoma. The aggregation and continuous degradation of a highly abundant misfolded protein
The mouse model of oxygen induced retinopathy is suitable for the study of various retinal neovascularization diseases,including retinopathy of prematurity.The maternally expressed gene 3(MEG3)has been demonstrated to have an inhibitory effect on diabetic
Wallerian degeneration is a complex biological process that occurs after nerve injury, and involves nerve degeneration and regeneration.Schwann cells play a crucial role in the cellular and molecular events of Wallerian degeneration of the peripheral nerv
Electron microscopy (EM) provides a unique ability to visualize structural detail with a resolution orders of magnitude better than other imaging techniques. Applied conventionally, its limitation is that each acquired image represents a small area with a
Dementia is currently the only leading cause of death that is still on the rise, with its overall costs already surpassing those of cancer and heart disease combined, it has developed into a worldwide crisis. In response to its serious and far-reaching ef