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转化生长因子-β（TGF）是一具有免疫调节活性的多肽分子，包括抑制T细胞和B细胞的分化以及灭活巨噬细胞功能。本研究建立兔同种异体偏中心穿透性角膜移植和异位角膜移植模型，观察了TGF-β对角膜移植排斥反应的影响。发现使用TGF-β具有延长移植片存活和抑制供体特异性迟发型超敏反应的作用。结果提示TGF-β具有作为免疫抑制剂抑制角膜移植排斥反应的能力。
Transforming growth factor-β (TGF) is an immunomodulatory polypeptide molecule that inhibits T cell and B cell differentiation and inactivates macrophage function. In this study, rabbit eccentric allograft penetrating keratoplasty and ectopic keratoplasty models were established to observe the impact of TGF-β on corneal graft rejection. The use of TGF-β was found to have the effect of prolonging graft survival and inhibiting donor-specific delayed-type hypersensitivity. The results suggest that TGF-β has the ability to inhibit corneal graft rejection as an immunosuppressive agent.