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检测了17例急性血吸虫病(急血)、14例慢性血吸虫病(慢血)和19例晚期血吸虫病(晚血)患者外周血单核细胞体外经脂多糖(LPS)诱生白细胞介素1(IL-1)的水平。结果急血组明显升高,且与体温呈正相关;慢血组和晚血组均显著下降,以晚血组尤为显著。经消炎痛阻断前列腺素合成,3组患者的IL-1水平均显著提高,而正常对照组无明显变化。表明IL-1在介导急血患者发热和炎症反应以及慢血感染阶段的免疫调节中可能起重要作用。血吸虫病中IL-1活性的改变可能与前列腺素关系密切。
A total of 17 patients with acute schistosomiasis (acute blood), 14 chronic schistosomiasis (slow blood) and 19 patients with advanced schistosomiasis (late blood) were tested for the production of interleukin-1 (IL-1) levels. Results The acute blood group was significantly increased, and the body temperature was positively correlated; slow blood group and late blood group were significantly decreased, especially in late blood group. The anti-inflammatory analgesia prostaglandin synthesis, three groups of patients with IL-1 levels were significantly increased, while the normal control group no significant change. It is indicated that IL-1 may play an important role in mediating fever and inflammation in acute blood-stasis patients and immune regulation in the stage of chronic infection. The change of IL-1 activity in schistosomiasis may be closely related to prostaglandin.