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目的研究P-选择素、C反应蛋白在糖尿病微血管病变中的临床意义。方法研究对象为168例DM患者及78例健康体检者,其中将168例DM患者分为微血管病变组85例和无微血管病变组83例,78例健康人作为健康对照(NC)组,测定其空腹血糖(FPG)、P-选择素、血清CRP。结果 168例DM患者的血清FPG、P-选择素、CRP均明显高于NC组,差异具有统计学意义(P<0.01);DM微血管病变组血清FPG、P-选择素、CRP均高于DM无微血管病变组,差异具有统计学意义(P<0.01)。并且P-选择素、CRP呈正相关,组间比较与对照组比较差异均有统计学意义(P<0.01)。结论表明P-选择素、CRP与糖尿病关系密切,通过检测Ps及CRP的水平,探讨其临床意义,为早期控制和预防糖尿病微血管病变的发生、发展提供理论依据。
Objective To study the clinical significance of P-selectin and C-reactive protein in diabetic microangiopathy. Methods 168 patients with DM and 78 healthy subjects were enrolled in this study. 168 DM patients were divided into microvascular disease group (85 cases), non-microvascular disease group (83 cases) and 78 healthy people as healthy control group (NC) Fasting plasma glucose (FPG), P-selectin, serum CRP. Results The serum levels of FPG, P-selectin and CRP in 168 DM patients were significantly higher than those in NC patients (P <0.01). The serum levels of FPG, P-selectin and CRP in DM microangiopathy group were higher than those in DM group No microvascular disease group, the difference was statistically significant (P <0.01). There was a positive correlation between P-selectin and CRP. The differences between the two groups were statistically significant (P <0.01). The results showed that P-selectin and CRP are closely related to diabetes. The detection of Ps and CRP levels and their clinical significance may provide a theoretical basis for the early control and prevention of the occurrence and development of diabetic microangiopathy.