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目的研究中药软肝纤消汤预防及治疗肝纤维化的作用。方法采用四氯化碳法造大鼠肝纤维化的模型,观察中药软肝纤消汤预防组和治疗组对肝纤维化大鼠血清中的天冬氨酸转氨酶(AST)、丙氨酸转氨酶(ALT)、谷氨酰转移酶(GGP)、血清总蛋白(TP)、白蛋白(ALB)、白/球比(A/G)、碱性磷酸酶(ALP)、乳酸脱氢酶(LDH)及对大鼠肝、脾指数和肝脏病理学变化的影响。结果中药软肝纤消汤预防组ALT、GGP、LDH、A/G、肝脾指数水平与模型组比较,差异有统计学意义(P<0.05);中药软肝纤消汤对肝细胞脂肪变性、肝细胞坏死、肝纤维组织增生有明显的预防作用(P<0.05)。中药软肝纤消汤治疗组血清中AST、BUN、脾指数与模型组相比,差异有统计学意义(P<0.05);中药软肝纤消汤对肝细胞脂肪变性、肝细胞坏死、肝纤维组织增生有明显的治疗作用。结论中药软肝纤消汤对四氯化碳所致大鼠肝纤维化具有预防和治疗作用。
Objective To study the role of Ruangangxianxiao decoction in prevention and treatment of liver fibrosis. Methods Carbon tetrachloride was used to establish a model of hepatic fibrosis in rats. The effects of Ruangangxianxiao decoction in prevention group and treatment group on serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), glutamyl transferase (GGP), serum total protein (TP), albumin (ALB), white / globular ratio (A / G), alkaline phosphatase (ALP), lactate dehydrogenase ) On liver and spleen index and hepatic pathological changes in rats. Results The levels of ALT, GGP, LDH, A / G and hepatopulmonary index of the rats treated with Ruganxianxiao decoction were significantly different from those of the model group (P <0.05) , Liver cell necrosis, liver fibrosis had a significant preventive effect (P <0.05). Compared with model group, AST, BUN and spleen index in the treatment group of Rugananxiao decoction of Chinese medicine were significantly different (P <0.05). The effect of Ruganxianghua decoction on fatty degeneration of liver cells, hepatocyte necrosis, Fibrosis has a significant therapeutic effect. Conclusion Chinese medicine Ruganxianghua Decoction can prevent and treat liver fibrosis caused by carbon tetrachloride in rats.