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巴西紫癜热(BPF)于1984年在巴西首先被认识,出现于1～10岁儿童,以急性发热起病,常伴呕吐和腹痛,有一先行的化脓性结膜炎。如不经治疗,可迅速进展,相继发生淤斑、紫癜、血管虚脱,并于症状开始后平均24～48小时死亡。广泛流行病学和实验室调查,排除了脑膜炎双球菌病,但尚未确定病因。本文作者报告从BPF患者的眼结膜和正常无菌部位分离出埃及嗜血杆菌。方法1986年3月,巴西Serrana镇发现一组
Purpura fever in Brazil (BPF) first recognized in Brazil in 1984, appeared in children aged 1 to 10, onset of acute fever, often accompanied by vomiting and abdominal pain, there is a first line of purulent conjunctivitis. Without treatment, rapid progress, ecchymosis, purpura, vascular collapse, and an average of 24 to 48 hours after the onset of symptoms of death. A wide range of epidemiological and laboratory investigations excluded meningococcal disease but the cause has not yet been determined. The authors report the isolation of Haemophilus influenzae from the conjunctival and normal sterile sites of BPF patients. Methods In March 1986, a group was found in Serrana, Brazil