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为了解氟暴露对工人机体脂质过氧化作用的影响以及“抗氟灵”的疗效，选接氟工人，分中毒组、接氟组和对照组，在服“抗氟灵”前后采血留尿测定血中ＬＰＯ、ＧＳＨ含量，ＧＳＨ－Ｐｘ、ＳＯＤ活性及尿氟、ＢＦ－４含量。结果可见服药前尿Ｆ－、血清ＬＰＯ中毒组和接氟组较对照组明显增高，尿ＢＦ－４、血ＧＳＨ、ＧＳＨ－Ｐｘ与ＳＯＤ与对照组未见显著差异。服药后ＢＦ－４、ＧＳＨ－Ｐｘ、ＳＯＤ比对照组显著升高，而尿Ｆ－、血ＬＰＯ升高与服药前比较变化不大。说明氟可使机体脂质过氧化作用增强，“抗氟灵”驱氟主要以ＢＦ－４形式排出，在体内氟负荷减轻时ＧＳＨ－Ｐｘ、ＳＯＤ抗氧化酶活性有代偿性增高，“抗氟灵”在干预氟对机体损伤方面有一定效果
In order to understand the effects of fluoride exposure on the body’s lipid peroxidation and the efficacy of “anti-flufen”, fluoride workers, sub-poisoning groups, fluoride-receiving groups and control groups were selected to collect urine before and after taking “ Blood LPO, GSH content, GSH-Px, SOD activity and urinary fluoride, BF-4 content were measured. The results showed that before taking the drug urinary F-, serum LPO poisoning group and fluoride group was significantly higher than the control group, urinary BF-4, GSH, GSH-Px and SOD and the control group no significant difference. After treatment, the levels of BF-4, GSH-Px and SOD were significantly higher than those of the control group, while the increase of urinary F- and blood LPO did not change much before treatment. Fluorine can enhance the body’s lipid peroxidation, ”Fluorine“ fluoride mainly in the form of fluoride discharge BF-4, in the body to reduce the load of fluorine GSH-Px, SOD antioxidant enzyme activity compensatory increase, ”anti Fluorine "in the intervention of fluoride on the body damage has a certain effect