论文部分内容阅读
我們抽驗药房片剂时,發現有將西皮氏1号散改以水制粒轧片的,其崩解度極坏,此由于氧化鎂与水作用生成氢氧化镁,在少量水中結成水泥样硬塊所致。本品有改用醇制顆粒,新压好的片剂具有良好的崩解度,于36—38℃水中立即全部崩散,但对存放約一星期的片剂进行檢查时,却發現崩解时限已远超过一般片剂規定,甚至一小时亦不能全部崩解。药房同志提出这与貯存时的容器密閉有关,于是我們进行观察存放过程的
When we took out the pharmacy tablets, we found that there was Sipi-1 on the change to water granulation and rolling tablets, the disintegration degree is very bad, which due to magnesium hydroxide and water to produce magnesium hydroxide, cement in a small amount of water to form a lump Due. This product has been converted to alcohol particles, the new good tablets have good disintegration, all immediately collapse in water at 36-38 ℃, but when stored for about a week to check the tablet, but found disintegration The time limit has far exceeded the general tablet requirements, and it can not even collapse in an hour. The pharmacy commented that this was related to the container airtightness when stored, so we looked at the storage process