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目的 :了解重组人干扰素α 2b乳膏和凝胶2种制剂预防尖锐湿疣 (CA)复发的疗效 ,并比较 2药的效果。方法 :6 0例CA病人均行二氧化碳激光治疗去除疣体。 2 0例局部用干扰素乳膏 ,2 0例局部用干扰素凝胶 ;对照组 2 0例局部不用任何药物。结果 :对照组CA复发率为 75 % ,明显高于治疗组(P <0 .0 1)。外用乳膏组复发率为 15 % ,外用凝胶组复发率为 10 % ,2组之间无显著差异 (P >0 .0 5 )。结论 :激光治疗CA去除疣体后继续局部应用重组人干扰素α 2b ,可明显降低CA的复发率。干扰素乳膏和凝胶疗效均满意。
Objective: To understand the efficacy of recombinant human interferon α 2b cream and gel in preventing the recurrence of condyloma acuminatum (CA) and to compare the effects of the two drugs. Methods: 60 cases of CA patients were treated with carbon dioxide laser treatment of warts. 20 cases of local interferon cream, 20 cases of local interferon gel; 20 cases of the control group without any local drug. Results: The recurrence rate of CA in the control group was 75%, which was significantly higher than that in the treatment group (P <0.01). The rate of recurrence in topical cream group was 15%, while that in topical gel group was 10%. There was no significant difference between the two groups (P> 0.05). CONCLUSIONS: After laser treatment of CA, removal of wart followed by topical application of recombinant human interferon alfa 2b can significantly reduce the recurrence rate of CA. Interferon cream and gel are satisfactory.