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目的探讨IL-17基因单核苷酸多态性(SNPs)与宫颈癌的关系。方法病例组选择2013年1月-2015年1月在吉化集团公司总医院经过病理确诊的60例宫颈癌患者,对照组为随机选取的同期50例健康志愿者。收集血液标本,提取基因组DNA,检测IL-17基因位点(rs2275913和rs763780)SNPs。结果宫颈癌组IL-17 rs2275913和rs763780位点基因型分布频率明显高于对照组,与宫颈癌转移呈正相关。结论 IL-17 rs2275913和rs763780位点基因型与宫颈癌发生密切相关。
Objective To investigate the relationship between single nucleotide polymorphisms (SNPs) of IL-17 gene and cervical cancer. Methods The cases were selected from January 2013 to January 2015 in 60 patients with cervical cancer confirmed by pathology in the General Hospital of Jihua Group and 50 healthy volunteers in the control group randomly. Blood samples were collected, genomic DNA was extracted, and SNPs at the IL-17 gene locus (rs2275913 and rs763780) were detected. Results The frequency of genotype distribution of IL-17 rs2275913 and rs763780 in cervical cancer group was significantly higher than that in control group, which was positively correlated with cervical cancer metastasis. Conclusion The genotypes of IL-17 rs2275913 and rs763780 are closely related to the occurrence of cervical cancer.