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云南红豆杉Taxus yunnanensis Chenget L.K.Fu木部被中国云南省几个少数民族用作传统药物。作者对该植物木部的化学成分及其抗癌活性进行了研究。该植物木部干粉依次用水、甲醇-水(1∶1)、甲醇提取,从水提取物的乙酸乙酯溶部位分得3个已知木脂素,即开环异落叶松树脂酚(5)、taxiresionol 和 isotaxiresinol。甲醇-水和甲醇提取物的二氯甲烷溶部位合并后多次经硅胶柱层析分得3个新的 C 14氧化紫杉烷类二萜 hongdoushans A～C(1～3),均为无色无定形固体。化合物1[a]_D~(25)+81.3°(c,
Taxus yunnanensis Chenget L.K.Fu Taxus yunnanensis is used as a traditional medicine by several ethnic minorities in Yunnan Province, China. The authors studied the chemical composition of the plant wood and its anticancer activity. The plant wood dry powder was successively extracted with water, methanol-water (1 : 1) and methanol, and 3 known lignans were obtained from the ethyl acetate solution part of the water extract, ie, ring-opening isoglasone resin phenol (5). ), taxiresionol and isotaxiresinol. The methanol-water and methanol extracts were dissolved in methylene chloride solution and several times were purified by silica gel column chromatography to obtain three new C 14 oxidative taxanes, ie, hongdoushans A to C (1 to 3). Amorphous solid. Compound 1[a]_D~(25)+81.3°(c,