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六十年代初,发现早孕时应用反应停(Thslidamide),致使娩出的婴儿出现无肢或短肢畸形后,接着又证实了妊娠时使用已稀雌酚,致使她们的女性后代,在年轻时期(19~20岁)易患生殖道透明细胞癌或阴道腺病(男性后代也会产生睾丸发育不良,副睾囊肿或隐睾、精子缺陷等).近二十余年来才对孕妇用药对胎儿的影响引起了重视;因为很多药物对胎儿的确切影响还不甚了解,惟恐药物对胎儿产生不良影响,认为在妊娠期应用任何药物都是有害的,以至延误病情.而合理用药不仅为治疗孕妇合并症所必需,还可以减少合并症
In the early 1960s, Thslidamide was found in the first trimester of pregnancy, resulting in the emergence of a limb-free or short-limbed deformity, followed by confirmation of the use of diluted estrogen during pregnancy, resulting in their female offspring, 19 to 20 years of age) is susceptible to clear cell carcinoma of the reproductive tract or vaginal adenosis (male offspring will also produce testicular dysplasia, orchestillary cysts or cryptorchidism, sperm defects, etc.) For nearly 20 years before the pregnant women medication on the fetus Of the impact of attention; because many drugs on the exact impact of the fetus is not yet understood, lest drugs have adverse effects on the fetus, that the application of any drug during pregnancy are harmful, and even delay the disease and reasonable medication not only for the treatment of pregnant women Necessary complications, but also can reduce complications