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为探讨蛋白聚糖在动脉粥样硬化发生发展中的作用，观察牛主动脉硫酸肝素蛋白聚糖、硫酸软骨素蛋白聚糖、硫酸皮肤素－硫酸软骨素蛋白聚糖和三种蛋白聚糖的混合物对培养的人主动脉平滑肌细胞增殖的影响。用细胞计数计算硫酸肝素蛋白聚糖（１．５～７．０ｍｇ／Ｌ）对培养的人主动脉平滑肌细胞增殖的抑制率分别为０、５５％和７６％；硫酸软骨素蛋白聚糖（１５．０～６０．０ｍｇ／Ｌ）的抑制率分别为２３％、３４％和６５％；硫酸皮肤素－硫酸软骨素蛋白聚糖（１５．０～６０．０ｍｇ／Ｌ）的抑制率分别为１９％、３７％和５９％；三种蛋白聚糖混合物（１０．５～４２．０ｍｇ／Ｌ）的抑制率分别为３３％、５５％和６５％。用氚标胸腺嘧啶脱氧核苷掺入法计算硫酸肝素蛋白聚糖（１．５～７．０ｍｇ／Ｌ）对培养的人主动脉平滑肌细胞增殖的抑制率分别为０、６８％和９１％；硫酸软骨素蛋白聚糖（１５．０～６０．０ｍｇ／Ｌ）的抑制率分别为４８％、６６％和８０％；硫酸皮肤素－硫酸软骨素蛋白聚糖（１５．０～６０．０ｍｇ／Ｌ）的抑制率分别为４９％、６３％和７２％；三种蛋白聚糖混合物（１０．５～４２．０ｍｇ／Ｌ）的抑制率分别为６５％、７９％和９１％。结果表明，硫酸乙酰肝素蛋白聚糖、硫酸软?
To investigate the role of proteoglycan in the development of atherosclerosis, we observed the effects of bovine aortic glycolethersulfate, chondroitin sulfate proteoglycan, dermatan sulfate-chondroitin sulfate proteoglycan and three proteoglycans Effect of mixture on the proliferation of cultured human aortic smooth muscle cells. The inhibitory rates of heparin sulfate proteoglycans (1.5-7.0 mg / L) on the proliferation of cultured human aortic smooth muscle cells were 0, 55% and 76%, respectively. The concentration of chondroitin sulfate proteoglycan . The inhibitory rates of dermatan sulfate-chondroitin sulfate proteoglycan (15.0 ~ 60.0 mg / L) were 23%, 34% and 65%, respectively %, 37% and 59% respectively. The inhibitory rates of three proteoglycan mixtures (10.5 ~ 42.0 mg / L) were 33%, 55% and 65%, respectively. The inhibitory rates of heparin sulfate proteoglycans (1.5-7.0 mg / L) on proliferation of cultured human aortic smooth muscle cells were 0, 68% and 91%, respectively, with tritiated thymidine incorporation. The inhibitory rates of chondroitin sulfate proteoglycan (15.0 ~ 60.0mg / L) were 48%, 66% and 80%, respectively. Dermatan sulfate - chondroitin sulfate proteoglycan (15.0 ~ 60.0mg / L) were 49%, 63% and 72%, respectively. The inhibitory rates of three proteoglycan mixtures (10.5 ~ 42.0mg / L) were 65%, 79% and 91%, respectively. The results show that heparan sulfate proteoglycan, sulfuric acid soft?