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对31例由内窥镜证明是十二指肠溃疡患者进行检查,在治疗前和每天睡前用50毫克甲丙咪嗪(Trimipramine)或安慰剂治疗后4周,按议定方案记录症状和副作用。结果证明:在14例接受甲丙咪嗪治疗的患者中,有12例的溃疡于开始治疗后4周愈合;17例接受安慰剂的病例中,9例的溃疡愈合。两组消化性溃疡的愈合差异有统计学意义(P<5％)。在接受甲丙咪嗪治疗的一组中,6例于治疗2周后,5例于治疗4周后出现疲乏、口干等副作用。在安慰剂组中,5例于用药后的第2周出现副作用,2例在第4周出
Thirty-one patients with endoscopically proven duodenal ulcer were examined and symptoms and side effects were recorded as prescribed before and 4 days after treatment with 50 mg of trimipramine or placebo daily before going to bed . The results showed that in 14 of the patients treated with imipramine, 12 of the ulcers healed 4 weeks after the start of treatment; of the 17 placebo-treated patients, 9 of the ulcers healed. There was significant difference between the two groups in the healing of peptic ulcer (P <5%). In the group receiving the treatment with acepromazine, 6 patients were tired after 2 weeks of treatment and 5 patients had side effects such as dry mouth after 4 weeks of treatment. In the placebo group, 5 patients showed side effects in the 2nd week after treatment, and 2 patients showed a side effect in the 4th week