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胰岛素样生长因子(IGF)系统主要包括胰岛素样生长因子(IGFs包括IGF-Ⅰ,IGF-Ⅱ),IGF受体(包括IGF-Ⅰ受体,IGF-Ⅱ受体)和胰岛素样生长因子结合蛋白(IGFBP,包括IGFBP-1～6).IGFs结构上与胰岛素部分同源,与特异性受体结合而发挥胰岛素样调节代谢和促进组织分化、发育的作用,并与胰岛素受体有一定的交叉反应,其作用活性受IGFBP调节.近年的研究发现,IGF系统与糖尿病及其并发症的发生、发展密切联系,正日益受到重视.本文旨在综述有关此方面的研究进展.1 IGF系统的一般特性1.1 IGF生理人血清中IGFs主要分为两种类型,IGF-Ⅰ和IGF-Ⅱ,主要来源于肝脏.胰岛素生长因子Ⅰ(IGF-Ⅰ,生长介素C)为分子量7.6kDa,含70个氨基酸的多肽,它调节GH的作用,IGF-Ⅰ还可抑制垂体产生GH.它与IGF-Ⅱ、胰岛素结构相似.在体内,IGF-Ⅰ由肝脏和多个其他组织所分泌,循环IGFs主要来源于
Insulin-like growth factor (IGF) system mainly includes insulin-like growth factor (IGFs including IGF-Ⅰ, IGF-Ⅱ), IGF receptors (including IGF-Ⅰ receptor, IGF- Ⅱ receptor) and insulin-like growth factor binding protein (IGFBP, including IGFBP-1 ~ 6) .IGFs are structurally homologous with insulin and bind with specific receptors to exert the role of insulin-like regulation of metabolism and promote tissue differentiation and development, and have some cross-reactivity with insulin receptor Response, and its role in the activity of IGFBP regulation.In recent years, studies have found that the IGF system and diabetes and its complications, the development is closely linked to the increasing attention.This paper aims to review the research progress in this area.1 General IGF system Features 1.1 IGF Physiological human serum IGFs are mainly divided into two types, IGF-Ⅰ and IGF-Ⅱ, mainly from the liver.Insulin growth factor Ⅰ (IGF-Ⅰ, Interleukin-C) molecular weight of 7.6kDa, containing 70 Amino acids, which regulate the role of GH, IGF-Ⅰ can also inhibit the production of pituitary GH. IGF-Ⅱ, insulin structure similar to in vivo, IGF-Ⅰ from the liver and many other organizations, the main source of circulating IGFs in