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经我们实验证明硝喹(Nitroquine)醋酸盐(CL_(679))对鼠疟(P.berghei)、鸡疟(P.gallinaceum)和食蟹猴疟(P.cynomolgi)均有较高的疗效。对被鸡疟子孢子感染的鸡有一定的病因性预防作用,并初步证明对猴疟有根治作用,对鸡疟、食蟹猴疟、人间日疟和恶性疟的孢子增殖有较强的阻断作用。为向临床应用过渡,又进行了动物实验,观察此药的急性、亚急性和慢性毒性反应,并确定其安全剂量范围。
Our experiments demonstrated that Nitroquine acetate (CL_ (679)) has a high efficacy against P. berghei, P. gallinaceum and P. cygnomgi. Chicken chickens infected with malaria sporozoites have a certain role in the prevention of etiology, and preliminary evidence of a cure for the monkey malaria, malaria, cynomolgous malaria, Plasmodium vivax and Plasmodium falciparum spores proliferation have a strong resistance Broken effect. In order to transition to clinical application, another animal experiment was conducted to observe the acute, subacute and chronic toxicity of this medicine and to determine its safe dose range.