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肾移植后的消化性溃疡、上消化道出血和胃、十二指肠穿孔的发生率为4～22%,其中消化道出血的死亡率高达50%以上。本文报告肾移植后病例用甲氰咪胺预防上消化道出血的效果。肾移植病人63例,分成两组,甲氰咪胺预防组30例,对照组33例,两组病情基本相同。预防组的甲氰咪胺用法如下:术后立即静注200mg,以后每12小时1次,根据病情改为口服,术后肾功能开始好转时候(血清肌酐<3.4mg/100ml)甲氰咪胺剂量增加到200mg,每日3次,睡前再用400mg,疗程为4～6周。2例近期确诊的十二指肠溃疡,在肾移植前3周就开始用甲氰咪胺。
Post-transplant peptic ulcer, upper gastrointestinal bleeding and stomach, duodenal perforation rate of 4 to 22%, of which the mortality of gastrointestinal bleeding as high as 50%. This article reports the use of mecalamine in the prevention of upper gastrointestinal bleeding after kidney transplantation. 63 cases of kidney transplantation patients were divided into two groups, 30 cases of cidcabamide prophylaxis group, 33 cases of control group, the two groups of the same disease. Cetamide was used in the prophylaxis group as follows: 200 mg intravenously immediately after surgery and once every 12 hours thereafter, depending on the condition and oral administration. Postoperative renal function began to improve (serum creatinine <3.4 mg / 100 ml) Dosage increased to 200mg, 3 times a day, 400mg before going to bed, treatment for 4 to 6 weeks. Two recently diagnosed duodenal ulcers were started with cidamethylamine 3 weeks prior to renal transplantation.