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目的比较结外鼻型NK/T细胞淋巴瘤和鼻咽部慢性炎症和扁桃体炎中EB病毒潜伏膜蛋白(LMP)1基因30bp碱基缺失的检出率,初步探讨结外鼻型NK/T细胞淋巴瘤中LMP1缺失型的检出意义及其与预后的关系。方法通过聚合酶链反应(PCR)检测55例结外鼻型NK/T细胞淋巴瘤和19例鼻咽部慢性炎症和扁桃体炎中EB病毒LMP1基因30bp的缺失情况,结合随访资料进行分析。结果结外鼻型NK/T细胞淋巴瘤中LMP1野生型和野生为主型9例,LMP1缺失型和缺失为主型46例;鼻咽部慢性炎症和扁桃体炎中LMP1缺失型和缺失为主型16例。LMP1缺失型和缺失为主型的检出率在NK/T细胞淋巴瘤与鼻咽部慢性炎症和扁桃体炎病例间差异无统计学意义(P>0.05)。结外鼻型NK/T细胞淋巴瘤中LMP1野生型和野生为主型病例比缺失型和缺失为主型病例预后好。结论不能简单地将LMP1缺失型作为结外鼻型NK/T细胞淋巴瘤的致病因素,但也不能完全否定其促进该淋巴瘤演进的作用。
Objective To compare the detection rate of 30 bp base deletion of Epstein - Barr virus latent membrane protein (LMP) 1 gene in extranodal nasal type NK / T cell lymphoma, nasopharyngeal chronic inflammation and tonsillitis, and to explore the relationship between extranodal nasal type NK / T Significance of detection of LMP1 deletion in cell lymphoma and its relationship with prognosis. Methods The deletion of 30 bp of LMP1 gene in 55 cases of extranodal nasal type NK / T cell lymphoma and 19 cases of nasopharyngeal chronic inflammation and tonsillitis was detected by polymerase chain reaction (PCR). The data of follow - up were analyzed. Results In extranodal nasal type NK / T cell lymphoma, LMP1 wild type and wild type were the main type in 9 cases, LMP1 type and deletion type were the predominant type in 46 cases. The chronic type of nasopharyngeal inflammation and tonsillitis were mainly LMP1 type and deletion Type 16 cases. The detection rate of LMP1 deletion and deletion was not significantly different between NK / T cell lymphoma and nasopharyngeal chronic inflammation and tonsillitis (P> 0.05). The extranodal nasal type NK / T cell lymphoma LMP1 wild-type and wild-type cases than the deletion type and deletion-based prognosis is good. Conclusion LMP1 deletion can not simply be used as a causative factor in extranodal nasal NK / T cell lymphoma, but it can not completely negate its role in promoting the development of this lymphoma.