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胰岛素抵抗 (IR)是缺血性心脑血管疾病的独立危险因素。凝血、纤溶异常是IR的重要病理组成部分 ,对于心血管疾病的发生、发展有着重要的意义。在IR状态下 ,脂肪组织合成的纤溶酶原激活物抑制因子 1(PAI 1)增多 ,同时因血管内皮细胞功能受损 ,一氧化氮 (NO)生成减少。使机体处于高凝血、低纤溶状态 ,促使动脉粥样硬化的发生。当B细胞功能失代偿而血糖升高后 ,机体糖基化终末产物 (AGE)生成增加 ,血管内皮细胞的损伤加重 ,凝血、纤溶异常进一步发展 ,加速动脉粥样硬化的形成。因此 ,深入研究IR状态下的凝血、纤溶异常及针对性治疗具有重要的临床意义。
Insulin resistance (IR) is an independent risk factor for ischemic cardiovascular and cerebrovascular diseases. Coagulation and fibrinolysis are important pathological components of IR, which are of great significance for the occurrence and development of cardiovascular diseases. In the IR state, synthesis of PAI-1 (PAI1) is increased in adipose tissue and nitric oxide (NO) production is reduced due to impaired vascular endothelial function. The body in a high blood coagulation, fibrinolytic state, to promote the occurrence of atherosclerosis. When B cell function is decompensated and blood sugar rises, the formation of advanced glycation end products (AGE), vascular endothelial cell injury aggravate, coagulation, fibrinolysis further development, accelerate the formation of atherosclerosis. Therefore, in-depth study of coagulation conditions, fibrinolytic disorders and targeted therapy has important clinical significance.