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目的 应用A型肉毒毒素治疗52例面肌痉挛病人,对病人病因,发病机理及治疗效果进行分析,观察A型肉毒毒素的疗效。方法 治疗前后均在本院专科门诊确诊、随访并行有关检查。使用兰州生物制品研究所生产的治疗用A型肉毒毒素(BTXA),注射剂量依据痉挛肌肉的大小、数量和痉挛程度以及治疗反应而定。采用多点肌内注射的方法。按Cohen等、Albert等痉挛强度分级。结果 经卡方检验, P<0.001,差异有极显著意义,BTXA注射治疗后眼睑及面肌痉挛明显减轻或消失。结论 国产A型肉毒素治疗面肌痉挛有效,应在有经验的医师指导下使用。
Objective To study the etiopathogenisis, pathogenesis and therapeutic effect of botulinum toxin type A in 52 cases of hemifacial spasm and to observe the curative effect of botulinum toxin type A. Methods Before and after treatment were diagnosed in our hospital specialist clinics, follow-up and parallel inspection. The therapeutic botulinum toxin type A (BTXA) produced by the Lanzhou Institute of Biological Products uses a dose that depends on the size, amount and spasticity of the spastic muscle and on the response to the treatment. Multi-point intramuscular injection method. By Cohen et al, Albert and other spasticity intensity classification. Results by chi-square test, P <0.001, the difference was extremely significant, BTXA injection treatment eyelid and hemifacial spasm significantly reduced or disappeared. Conclusion Domestic Botulinum toxin type A is effective in the treatment of hemifacial spasm and should be used under the guidance of experienced physicians.