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药物引起的呼吸系统的结构或功能的病变称为药原性呼吸病。药物对呼吸系统的损害,大多隐匿发生,往往没有特异性的临床表现和实验检查指标,一般在该药问世后的临床实践中逐步被人们认识和报道,有的甚至是在临床应用15～20年后才被认识。迄今为止,药物对呼吸系统的不良反应远没有像对肝、肾、骨髓等损害那样引起人们足够的重视和警惕。据报道,药物引起呼吸系统的病变约占药物引起全身不良反应的5％～8％,有一定的漏诊率,因此实际发病率可能还要高些。 1 发病机理 多数药原性呼吸病的发生机理尚不清楚,其阐明有赖于各基础学科尤其是细胞生物学和分子生物学的发展,目
The structure or function of the drug-induced respiratory system is called a drug-induced respiratory disease. Most of the damage to the respiratory system of the drug occult, there is often no specific clinical manifestations and laboratory tests, usually in the clinical practice of the drug after the advent of gradually be recognized and reported, and some even in clinical application of 15 to 20 After years of being recognized. To date, the adverse drug reactions to the respiratory system are far less of a cause for concern and vigilance than the damage to the liver, kidney, bone marrow, and others. It is reported that the drug causes respiratory system lesions account for about 5% to 8% of systemic adverse reactions caused by drugs, there is a certain misdiagnosis rate, so the actual incidence may be higher. 1 pathogenesis Most of the pathogenesis of drug-induced respiratory disease is not clear, its elucidation depends on the basic disciplines, especially the development of cell biology and molecular biology, the head