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建立小剂量~(14)-尿素呼气试验,结合胃镜、细菌培养和病理检查,对48例病人进行了研究。结果发现~(14)C-尿素呼气试验阳性者,胃镜下炎症程度及活动性明显高于阴性者。~(14)CO_2表达与胃粘膜炎症和Hp感染呈正相关。以~(14)CO_2值大于5000dpm作为筛选抗Hp感染临界值,所选病人经抗Hp治疗,症状、内镜下胃粘膜表现及Hp情况有明显疗效。提示,用~(14)C-尿素呼气试验可作为筛选抗Hp治疗指标之一,除避免了尿素酶试验,细菌培养和组织学检查受显色剂、培养条件及胃镜取材有局限性影响外,还解决了血清学不能确认Hp病人的问题,以~(14)CO_2值大于5000dpm选择治疗对象,可减少Hp耐药菌株和药物副作用的产生。
A small dose of ~ (14) - urea breath test was established. 48 cases of patients were studied with gastroscopy, bacterial culture and pathological examination. The results showed that ~ (14) C-urea breath test positive gastroscopy inflammation and activity was significantly higher than the negative. ~ (14) CO_2 expression was positively correlated with gastric mucosal inflammation and Hp infection. The value of ~ (14) CO_2> 5000dpm was used to screen the critical value of anti-Hp infection. The selected patients were treated with anti-Hp, and the symptoms, endoscopic gastric mucosa and Hp had obvious curative effect. Prompt, with ~ (14) C-urea breath test can be used as a screening index of anti-Hp treatment, in addition to avoiding the urease test, bacterial culture and histological examination by the chromogenic agents, culture conditions and gastroscopy have limitations In addition, it also solves the problem that serology can not confirm Hp patients. Choosing the treatment target with ~ (14) CO_2 greater than 5000dpm can reduce the generation of Hp resistant strains and drug side effects.