论文部分内容阅读
对合并应用TL与CsA后6只家兔体内CsA的药物动力学进行了研究.结果表明:合用TL对家兔体内CsA的AUC以及T_(1/2)无显著性影响(P>0.05),使CsA的Vc及CLs明显增大,差异有统计学意义(P<0.05).可能是由于TL在体内分布广泛,与组织亲和力强,降低了CsA的血浆蛋白结合率所致.提示临床合理地合用,TL有减少CsA体内蓄积的趋势.
The pharmacokinetics of CsA in 6 rabbits after combined application of TL and CsA was studied. The results showed that there was no significant effect of combined use of TL on AUC and T_(1/2) of CsA in rabbits (P>0.05). The Vc and CLs of CsA were significantly increased (P<0.05). This may be due to the fact that TL is widely distributed in vivo and has strong affinity with tissues, which reduces the plasma protein binding rate of CsA. In combination, TL has a tendency to reduce the accumulation of CsA in vivo.