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目的:探讨钙蛋白酶小亚基-1(Capn4)和核转录因子-κB2(p52)在结肠癌中的表达及临床意义,以及两者在结肠癌发生、发展过程中的相关性。方法:应用免疫组织化学方法检测70例结肠癌组织及35例癌旁正常结肠组织中Capn 4和p52的表达情况,并分析Capn 4和p52的表达与结肠癌临床病理特征的关系。结果:Capn 4及p52在结肠癌(74.3%、70.0%)中的表达明显高于癌旁正常结肠组织(22.9%、31.4%)(P<0.05),两者在结肠癌组织中表达与结肠癌的浸润深度、TNM分期以及有无淋巴结转移密切相关(P<0.05),与患者年龄、性别、分化程度无关(P>0.05),并且两者在结肠癌的发生发展中可能存在相关性(r=0.869,P<0.05)。结论:Capn 4和p52在结肠癌组织中高表达,提示两者可能与结肠癌的浸润、转移有关。两者的表达呈正相关,提示Capn 4可能通过NF-κB通路的非经典途径起作用。
Objective: To investigate the expression of calpain small subunit-1 (Capn4) and nuclear factor-kappaB (p52) in colon cancer and its clinical significance, as well as the correlation between them in the development and progression of colon cancer. Methods: The expression of Capn 4 and p52 in 70 cases of colon cancer and 35 cases of normal colorectal tissues were detected by immunohistochemistry. The relationship between the expression of Capn 4 and p52 and the clinicopathological features of colon cancer was analyzed. Results: The expression of Capn 4 and p52 in colon cancer (74.3%, 70.0%) was significantly higher than that in adjacent normal colorectal tissues (22.9%, 31.4%) (P <0.05) (P <0.05), but not with the age, sex and differentiation (P> 0.05), and there was a correlation between the two in the occurrence and development of colon cancer ( r = 0.869, P <0.05). Conclusion: Capn 4 and p52 are highly expressed in colon cancer tissues, suggesting that both may be related to invasion and metastasis of colon cancer. The positive correlation between the expression of Capn 4 suggests that NF-κB pathway may play a role in the non-classical pathway.