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目的探讨CT灌注参数血流量(BF)、表面通透性(PS)临界值对鼻咽癌(nasopharyngeal carcinoma,NPC)放疗后局部复发诊断的准确性。资料与方法回顾性分析150例NPC患者放疗后经CT灌注扫描资料,利用受试者工作特征(ROC)曲线分析BF、PS值对诊断NPC放疗后局部复发最佳临界值,计算BF、PS值临界值对诊断局部复发的预测值以及似然比(LR)。结果 CT灌注参数BF、PS临界值诊断NPC放疗后局部复发阳性预测值、阴性预测值分别为90.9%、89.2%和76.4%、70.1%;BF、PS临界值的阳性结果的LR分别为4.7和5,BF、PS阴性结果的LR分别为0.14和0.02。结论 CT灌注成像参数BF、PS临界值对诊断NPC放疗后局部复发具有较好预测值,并具有较好的LR,有助于NPC放疗后局部复发诊断。
Objective To investigate the diagnostic accuracy of CT perfusion parameters of blood flow (BF) and surface permeability (PS) threshold in local recurrence of nasopharyngeal carcinoma (NPC) after radiotherapy. Materials and Methods Retrospective analysis of 150 cases of NPC patients after CT perfusion scan data, the use of receiver operating characteristic (ROC) curve analysis of BF, PS value for the diagnosis of NPC local recurrence after radiotherapy the best critical value, calculated BF, PS value Prediction of local recurrence with predictive value and likelihood ratio (LR). Results The predictive values of CT and perfusion parameters BF and PS were 90.9%, 89.2% and 76.4%, 70.1% respectively after radiotherapy. The LR of positive results of BF and PS were 4.7 and 5, LR for BF and PS negative results were 0.14 and 0.02, respectively. Conclusion CT perfusion imaging parameters BF, PS critical value for the diagnosis of NPC local recurrence after radiotherapy has a good predictor, and has a good LR, is helpful in the diagnosis of local recurrence of NPC after radiotherapy.