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As a new inter-and multi-disciplinary forum for modeling,engineering and understanding life,our joual Quantitative Biology (QB) is celebrating its 6th anniversary and the start of a new Editorial Board in this issue.The past 6 years have evidenced tremendous progress in the research on computational biology,systems biology and synthetic biology.Omics studies have expanded from genomes and transcriptomes to multiple aspects of epigenomes and their interactions.Peoples understanding and modeling on genomes is becoming 3D or 4D.The development of high throughput single-cell genomics technologies has aroused huge enthusiasm for building the Human Cell Atlas as an ultimate reference for all future studies on human.And the rapid popularity of sequencing technologies in parallel with big-data technologies resulted in large-scale disease study projects like the UK BioBank project,the US All-of-Us Research Program,and the China Precision Medicine plan,all based on the collection of massive population health and genomics data.In the broad field of synthetic biology,technologies are enabling not only the "editing" and "Nriting" of genomic segments,but also the synthesis of entire eukaryote chromosomes.On the more basic level,scientists are beginning to design and make proteins that do not exist in nature,and even trying to expand the genetic alphabet by devising "unnatural" nucleotide bases and adding those new letters into genomes of living organisms like Escherichia coli.Such advances in basic research are accompanied with enthusiastic development of biological technologies for diagnosing and curing diseases,such as lipid biopsy diagnosis,immuno-therapies and stem-cell therapies for cancer and degenerative diseases.In the meanwhile,theoretical studies on modeling basic biological procedures like development,tumorigenesis and microevolution have also seen great advancement.