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东方至宝口服液(Dongfang ZhibaoKoufuye)原名少林至宝丹,为王月亭中医师的祖传秘方,在民间应用已百十余年。一九八五年由浙江处州制药厂与浙江医科大学药物研究检测中心、浙一医院、嵊县中草药研究所等单位共同进行开发研制而成。一、药理作用与用途东方至宝经急性毒性试验,测得 LD_(50)为215.71±4.29g/kg。又经不同剂量为期三个月的大鼠和狗长期毒性试验表明,对大鼠和狗的肝、肾功能以及血象中的白细胞总数、分类及血红蛋白均无影响,同时发现大剂量及中剂量给药组,大鼠体重比对照组增长为快。病理切片检查证实本品不同剂量对大鼠脏器无损害,该试验为长期服用的安全性提供了依据。
Dongfang Zhibao Oral Liquid (Dongfang ZhibaoKoufuye), formerly known as Shaolin to Baodan, is the ancestral secret of Wang Yueting’s traditional Chinese medicine practitioners. It has been used for more than one hundred years in folk practice. In 1985, it was jointly developed by Zhejiang Chuzhou Pharmaceutical Factory and Zhejiang Medical University Drug Research and Testing Center, Zhejiang First Hospital, and Qixian Chinese Herb Research Institute. First, pharmacological effects and uses Oriental treasure to the acute toxicity test, measured LD_ (50) was 215.71 ± 4.29g/kg. Long-term toxicity tests in rats and dogs with different doses for a period of three months showed that there was no effect on liver and kidney function and blood leukocyte count, classification, and hemoglobin in rats and dogs. Large doses and medium doses were also found. In the drug group, the body weight of rats increased faster than that of the control group. Pathological biopsy confirmed that the different doses of this product did not damage the organ in rats. This test provided a basis for the safety of long-term use.