论文部分内容阅读
丙型肝炎病毒(hepatitis C virus,HCV)是丙型肝炎的病原体,是导致输血后肝炎和非甲非乙型肝炎的主要致病因子。HCV感染常导致慢性肝炎、肝硬化和肝细胞癌。HCV在细胞内和动物体内复制能力很差,没有理想的细胞模型和动物模型。丙型肝炎目前尚无疫苗,还有很多病人在等待治疗。研制预防性和治疗性疫苗,以控制HCV感染有着重要意义。经过几代科技工作者的努力和奉献,丙型肝炎疫苗研究取得了重大进展。用核酸疫苗作首次免疫,用多肽疫苗或树突状细胞疫苗作加强免疫,不但有预防作用,而且有治疗效果。核酸疫苗将为改善人类和动物健康作出巨大贡献。
Hepatitis C virus (HCV) is the causative agent of Hepatitis C and is the leading causative agent of post-transfusion hepatitis and non-A non-B hepatitis. HCV infection often leads to chronic hepatitis, cirrhosis and hepatocellular carcinoma. HCV replicates poorly in cells and in animals, with no ideal cell model or animal model. Hepatitis C is currently no vaccine, there are many patients waiting for treatment. The development of prophylactic and therapeutic vaccines to control HCV infection is of great importance. After several generations of scientific and technological workers efforts and dedication, hepatitis C vaccine research has made significant progress. The first immunization with nucleic acid vaccine, peptide vaccine or dendritic cell vaccine for enhanced immunity, not only preventive effect, but also the therapeutic effect. Nucleic acid vaccines will make a huge contribution to improving the health of humans and animals.