论文部分内容阅读
本文探讨不明原因肝功能异常患者中自身抗体检测阳性率、自身免疫性肝病检出率及临床意义。回顾性分析54例患者临床资料、自身抗体检测结果和最后诊断。结果表明抗核抗体(ANA)、抗线粒体抗体M2亚型(AMA-M2)、抗可溶性肝抗原抗体/抗肝胰抗原抗体(SLA/LP)阳性率分别为50%、27.8%、1.9%。原发性胆汁性肝硬化(PBC)及身免疫性肝炎(AIH)检出率分别为31.5%、5.5%,未检出原发性硬化性胆管炎(PSC)。PBC患者AMA-M2阳性率显著高于其他患者。认为自身抗体检测有助于自身免疫性肝病的诊断和分类。
This article explores the detection of autoantibodies in patients with unexplained liver dysfunction, the detection rate of autoimmune liver disease and clinical significance. Retrospective analysis of 54 patients with clinical data, autoantibodies test results and the final diagnosis. The results showed that the positive rates of ANA, AMA-M2 and SLA / LP were 50%, 27.8% and 1.9% respectively. The detection rates of primary biliary cirrhosis (PBC) and autoimmune hepatitis (AIH) were 31.5% and 5.5%, respectively. No primary sclerosing cholangitis (PSC) was detected. The positive rate of AMA-M2 in PBC patients was significantly higher than that in other patients. Autoantibodies are thought to contribute to the diagnosis and classification of autoimmune liver disease.