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目的观察戊酸雌二醇、安宫黄体酮降低稽留流产术后并发症的临床效果。方法选取2013年7月-2014年7月苍南县妇幼保健院妇产科收治的稽留流产患者100例,随机分为观察组及对照组,均给予口服米非司酮及人工流产术治疗,而观察组患者再给予口服戊酸雌二醇片及安宫黄体酮治疗,观察治疗效果。结果两组患者间手术时间及术中出血量差异无统计学意义(P>0.05),观察组术后阴道出血时间、月经复潮时间均小于对照组,而术后21 d子宫内膜厚度大于对照组,且差异有统计学意义(P<0.05)。观察组盆腔压痛,周期性下腹痛及闭经等并发症发生率显著性低于对照组(P<0.05)。两组患者间腹泻、发热、疲乏、麻木及恶心呕吐等不良反应发生率差异均无统计学意义(P>0.05)。结论戊酸雌二醇联合安宫黄体酮治疗稽留流产临床效果满意,可有效降低术后并发症发生率,且安全性佳,值得临床推广应用。
Objective To observe the clinical effect of estradiol valerate and Andronesin on reducing complications after missed abortion. Methods Totally 100 missed abortion patients admitted to Obstetrics and Gynecology Hospital of Cangnan Maternal and Child Health Hospital from July 2013 to July 2014 were randomly divided into observation group and control group. All patients were given oral mifepristone and artificial abortion Patients in the observation group were given orally administered estradiol valerate tablets and progesterone acetate, and the therapeutic effect was observed. Results There was no significant difference in operative time and intraoperative blood loss between the two groups (P> 0.05). The postoperative vaginal bleeding time and menstrual period were shorter in the observation group than in the control group, while the thickness of the endometrium on 21 d after operation Control group, and the difference was statistically significant (P <0.05). Observation group pelvic tenderness, periodic lower abdominal pain and amenorrhea and other complications was significantly lower than the control group (P <0.05). There was no significant difference in the incidence of adverse reactions such as diarrhea, fever, fatigue, numbness, nausea and vomiting between the two groups (P> 0.05). Conclusions The combination of progesterone valerate and isoprenoid progesterone in treatment of missed abortion is effective, which can effectively reduce the incidence of postoperative complications and is safe and worthy of clinical application.