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Objective. Endometrial stromal sarcomas (ESS) are very rare neoplasms constitu ting less than 0.5%of all malignant uterine tumors. The aim of the present stud y was to characterize the karyotypic abnormalities in these malignant mesenchyma l tumors and to find specific chromosomal aberrations with eventual correlation with histologic grades. Methods. Twelve cases of endometrial stromal sarcomas co nsisting of nine lowgrade ESS and three undifferentiated endometrial sarcomas (U ES) were investigated by comparative genomic hybridization (CGH). Results. Ten o f the twelve cases (83.3%) displayed chromosomal gains or losses. Deletions occ urred more frequently than gains (63.4%versus 36.6%). In low-grade ESS, gains on 1, 6q, 9q, 16p, 19, 20q, 22q and losses on 2, 4q, 6, 7, 11q, 13q, 15q, 16q, 20p, X were detected. CGH with UES exhibited gains on 2q, 4q, 6q, 7p, 9q, 20q an d losses on 3q, 10p, 14q. One low-grade ESS and one UES did not reveal any chro mosomal aberration. Conclusions. Chromosomal aberrations in endometrial sarcomas are heterogeneous and do not clearly correlate with the histologic grades. Ther e is no increased accumulation of aberrations from low-grade ESS to UES. Despit e the karyotypic variations, chromosomal deletion on 7p was the most common find ing (55.6%) in low-grade ESS and may play a role in tumor development and prog ression.
Objective. The aim of the present stud y was to characterize the karyotypic abnormalities in these malignant mesenchyma l tumors and to find specific chromosomal aberrations with Twelve cases of endometrial stromal sarcomas co nsisting of nine lowgrade ESS and three undifferentiated endometrial sarcomas (U ES) were investigated by comparative genomic hybridization (CGH). Results. Ten of the twelve cases (83.3%) Deletions occ urred more frequently than gains (63.4% versus 36.6%). In low-grade ESS, gains on 1, 6q, 9q, 16p, 19, 20q, 22q and losses on 2, 4q, 6 One Low-grade ESS and 10q, 14q., 7q, 13q, 15q, 16q, 20p, X were detected. CGH with UES measurement gains on 2q, 4q, 6q, one UES did not reveal any chro mosomal aberration. Conclusions. Chromo somal aberrations in endometrial sarcomas are heterogeneous and do not clearly correlate with the histologic grades. Ther e is no increased accumulation of aberrations from low-grade ESS to UES. Despit e the karyotypic variations, chromosomal deletion on 7p was the most common find ing ( 55.6%) in low-grade ESS and may play a role in tumor development and prog ression.