L-Arg和L-NAME对窒息新生鼠血浆ET及NO的影响

• 作 者: 王玲 侯英萍 鱼绥和
• 机 构: 第四军医大学第二临床医学院儿科!710038,第四军医大学第一临床医学院核医学科!710032,第四军医大学第二临床医学院儿科!710038
• 出 处: 新生儿科杂志
• 发表日期: 2000年06期
• 关键词: 窒息 精氨酸L-硝基-精氨酸甲酯 内皮素 一氧化氮

To expore the effect of L Arg and L NAME on serum endothelin (ET) and nitric oxide (NO) in newborn rats with asphyxia 70 determine the serum levels of ET and NO were measured in newborn rats in asphyxia. normal L Arg. L NAME. Result shovoed that the level of serum ET in rats with asphyxia was signifcantly higher (P<0.01), The level of serum NO was higher than those of controls, but there was no significant difference (P<0.05); The serum ET level of L Arg group was significant lower than the rats with asphyxia (P<0.01), but The serum NO level significant. increased (P<0.01); The serun ET level of L NAME group was significant higher than other group (P<0.01), but The serum NO level was no significant decreased than the rats with asphyxia (P<0.01). Thereboie, L Arg plays an important rule not only in increaseing NO level but also in reducing ET level; The effect of L NAME was no difference with L Arg

To expore the effect of L Arg and L NAME on serum endothelin (ET) and nitric oxide (NO) in newborn rats with asphyxia 70 determine the serum levels of ET and NO were measured in newborn rats in asphyxia. Normal L Arg. L NAME . Results shovoed that the level of serum ET in rats with asphyxia was signifcantly higher (P <0.01), The level of serum NO was higher than those of controls, but there was no significant difference (P <0.05); The serum ET level (P <0.01); The serun ET level of L NAME group was significantly higher than other groups (P <0.01) ), The Therapeutic NO level was no significant decreased than the rats with asphyxia (P <0.01). Thereboie, L Arg plays an important rule not only in increasing NO level but also in reducing ET level; The effect of L NAME was no difference with L Arg