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众所周知,针对血小板抗原的自身抗体是慢性免疫性血小板减少性紫瘢(ITP)的原因。本文报道第一例抗血小板纤维蛋白受体(Ⅱb/Ⅲa)的自身抗体,在临床上引起显著的血小板功能失常。患者,女,33岁,1976年9月,根据其淋巴结活检和临床表现,被诊断为何杰金氏病,结节硬化型,Ⅳ期A组。经12疗程的MOPP治疗完全缓解,1980年3月因纵膈扩大,又经历了6疗程的ABVD治疗,病人感觉良好,直到1982年7月未再用任何治疗。之后,病人出现反复发作的皮肤淤点和淤斑,血小板计数(BPC)20×10~9/l,骨髓检查除巨核细胞增生外,余皆正常,病人被诊断为ITP,给予强的松(pred)
It is well known that autoantibodies to platelet antigens are responsible for chronic immunological thrombocytopenic purpura (ITP). This article reports the first autoantibody against platelet fibrin receptor (IIb / IIIa) that causes clinically significant platelet dysfunction. The patient, female, 33 years old, September 1976, was diagnosed with Hodgkin’s disease, nodular sclerosis and stage IV A on the basis of his lymph node biopsy and clinical presentation. After 12 courses of MOPP treatment of complete remission, in March 1980 due to the expansion of the mediastinum, went through 6 cycles of ABVD treatment, the patient feels good until July 1982 without any treatment. After that, the patient developed recurrent skin petechia and ecchymosis. The platelet count (BPC) was 20 × 10-9 / l. Except for megakaryocyte hyperplasia, the bone marrow examination was more than normal. The patient was diagnosed as ITP and given prednisone pred)