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目的 比较经腹腔镜下贲门肌层切开术(LHM)和经口内镜下肌切开术(POEM)治疗贲门失弛缓症的临床疗效,并比较两组患者手术前后的焦虑、抑郁情绪水平.方法 取2015年10月～2019年10月陆军特色医学中心确诊的53例贲门失弛缓症患者资料纳入该研究,其中28例于胸外科接受LHM及部分胃底前壁折叠术,25例于消化内科接受POEM.收集所有患者临床基本资料、手术情况、术前及术后3个月的贲门失弛缓症临床症状评分系统(Eckardt)、食管测压结果、术前及术后3个月的汉密尔顿焦虑量表(HAMA)及汉密尔顿抑郁量表(HAMD)评分.结果 全部患者顺利完成手术.两组患者在手术时间、出血量、术后住院日、住院费用等方面的差异无统计学意义(P＞0.05);所有患者术后Eckardt评分、下段食管静息压(LES)均较术前有明显下降,组间比较无明确统计学意义(P＜0.05);所有患者术后焦虑评分、抑郁评分均低于术前(P＜0.05),接受POEM的患者组术后焦虑评分略高于LHM组(P＜0.05).结论 贲门失弛缓症首选手术治疗,LHM及POEM治疗贲门失弛缓症均能有效缓解临床症状,POEM术后患者焦虑水平略高于LHM术后患者.“,”Objective To compare the laparoscopic heller myotomy (LHM) and peroral endoscopic myotomy (POEM) outcomes of those patients who suffered from esophageal achalasia, and to study their anxiety and depression level. Methods 53 patients diagnosed with esophageal achalasia in the Third Affiliated Hospital and Research Institution of Surgery of Army Medical University from October 2015 to October 2019 were recruited to this study. Among them, 25 underwent POEM and the other 28 underwent LHM with Dor. Evaluating these patients with Eckardt score, esophageal pressure, Hamilton anxiety scale (HAMA) and Hamilton depression scale (HAMA) score. The assessments took place before and three months after surgery. Results All patients successfully completed the operation. There was no significant difference between the two groups of patients in terms of operation time, blood loss, postoperative hospital stay, hospitalization expenses, etc. (P＞0.05); the Eckardt score and lower esophageal resting pressure(LES) of all patients were higher than those before surgery There was a significant decrease, and there was no clear statistical significance between groups (P＜0.05); all patients\'\' postoperative anxiety and depression scores were lower than before surgery (P＜0.05), and the postoperative anxiety scores of patients receiving POEM were slightly higher LHM group (P＜0.05). Conclusion Surgery is the first-line therapy for achalasia nowadays. Both surgeries show clinical application value. Patients underwent POEM shows higher anxiety level than those underwent LHM with Dor.