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目的:评价早期高剂量美托洛尔对老年急性心肌梗死患者的临床疗效果。方法:选取2014年1月—2015年1月间收治的老年急性心肌梗死患者112例,将其分为观察组患者和对照组,各56例;观察组患者患者早期均给予高剂量美托洛尔治疗,对照组患者均给予卡托普利与单硝酸异山梨酯缓释胶囊联用治疗,评价两组患者治疗后的临床疗效。结果:观察组患者治疗后总有效率为96.43%高于对照组为58.93%(P<0.05);心律失常发作率为19.64%低于对照组为50.0%(P<0.05);观察组患者胸痛时间、胸痛发作次数、泵衰竭率、心率均优于对照组(P<0.05);CK-MB峰值、CK-MB峰值时间和病死亡率均低于对照组(P<0.05)。结论:早期高剂量美托洛尔对老年急性心肌梗死患者具有较好临床疗效,并不增加不良反应的发生率。
OBJECTIVE: To evaluate the clinical efficacy of early high-dose metoprolol in elderly patients with acute myocardial infarction. Methods: A total of 112 elderly patients with acute myocardial infarction who were admitted between January 2014 and January 2015 were selected and divided into observation group and control group, with 56 cases in each group. Patients in observation group were given high dose metoprolol In the control group, both captopril and isosorbide mononitrate sustained-release capsules were given together to evaluate the clinical effect of the two groups after treatment. Results: The total effective rate of the observation group was 96.43%, which was significantly higher than that of the control group (58.93%, P <0.05). The incidence of arrhythmia was 19.64%, which was lower than that of the control group (50.0%, P <0.05) (P <0.05). The peak of CK-MB, the peak time of CK-MB and the mortality of CK-MB were lower than those of the control group (P <0.05). Conclusion: Early high-dose metoprolol has good clinical efficacy in elderly patients with acute myocardial infarction, and does not increase the incidence of adverse reactions.