论文部分内容阅读
大环内酯类乃一类含12～22个碳原子的内酯药物,最早发现者为红霉素(1952年)。此后陆续生产出碳霉素、三乙酰竹桃霉素、乙酰螺旋霉素、柱晶白霉素、麦迪霉素、交沙霉素、玫瑰霉素等。国内生产者有红霉素碱(口服)、红霉素月桂酸酯(口服,也称“无味红霉素”)红霉素乳糖酸盐(静脉滴注)、乙酰螺旋霉素(口服)、麦迪霉素(口服)、麦迪霉素酒石酸盐(静脉滴注)等,柱晶白霉素也已试制成功。就抗菌谱和抗菌活性而言,上述各品种基本上均与红霉素相似,甚或略有不及,因而本类中目前仍以红霉素为主要代表,其应用也最为广泛。近年来虽出现了一些新品种,但仍缺少令人嘱目的突破。
Macrolides are a class of lactone drugs containing 12 to 22 carbon atoms, the earliest discovered by erythromycin (1952). Since then, one after another in the production of carbemycin, three acetysellaomycin, acetylspiramycin, leucomycin, midecamycin, jasminemycin, such as roses. Domestic producers of erythromycin alkali (oral), erythromycin laurate (oral, also known as “odorless erythromycin”) erythromycin lactobionate (intravenous infusion), acetyl spiramycin (oral) Midecamycin (oral), midecamycin tartrate (intravenous infusion), etc., column crystal white mold has also been successfully trial. In terms of antibacterial spectrum and antibacterial activity, the above varieties are basically similar to erythromycin, or even slightly less, so this class is still the main representative of erythromycin, its most widely used. Although some new varieties have appeared in recent years, they still lack the goal of making breakthroughs.