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原发性肝癌被视为多基因遗传病,同时,又是多种因素共同作用的产物。为探讨其遗传病因、病理形态及其预后方面的特征,本文将本所手术的152例病例,均分有、无家族史两组进行分析比较。结果显示,肝癌家族聚集现象和高发家族的存在;有家族史组患病高峰年龄提前,患者发病年龄偏低;乙型肝炎病毒感染率和肝炎曾患率明显高于对照组;病理形态除肿瘤大小、瘤栓多少及肿瘤部位等项外,其它数项无显著差异;术后一、三、五年生存率对照组似比有家族史组为好。
Primary liver cancer is regarded as a polygenic hereditary disease. At the same time, it is a product of multiple factors. In order to investigate its genetic etiology, pathological morphology and its prognostic features, we analyzed and compared the 152 cases of our surgery with or without family history. The results showed that the family clustering phenomenon of HCC and the presence of a high-family family; the peak age of the family history group was earlier and the age of onset of the patient was younger; the infection rate of hepatitis B virus and the prevalence of hepatitis were significantly higher than that of the control group; the pathological morphology was divided by the tumor size. There were no significant differences among other items except tumor thrombus, tumor site, etc. The 1-, 3-, and 5-year survival rate of the control group was better than that of the family history group.