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目的胆囊小细胞癌罕见,起病隐匿,预后差。文中结合临床病例并复习文献,以提高对胆囊小细胞癌的认识。方法报道1例胆囊小细胞癌,经手术切除及组织病理学证实,术后行全身化疗。结合文献对胆囊小细胞癌的发生、临床表现、组织学特点、治疗原则等进行讨论。结果胆囊小细胞癌临床症状以及影像学检查无特征性表现,需经病理组织以及免疫组化方法明确,细胞质内常表达神经元特异性烯醇化酶、突触素或嗜铬蛋白。结论该病是一种罕见的恶性肿瘤,容易误诊,组织病理和免疫组化对该病诊断具有重要价值,联合手术和化疗可以提高生存期。
Purpose gallbladder small cell carcinoma is rare, occult onset, poor prognosis. The article combines clinical cases and review the literature to raise awareness of small cell carcinoma of the gallbladder. Methods One case of small cell carcinoma of gallbladder was reported. Surgical resection and histopathology confirmed that systemic chemotherapy was performed after operation. With the literature on the occurrence of gallbladder small cell carcinoma, clinical manifestations, histological features, treatment principles are discussed. Results The clinical symptoms of gallbladder small cell carcinoma and imaging examination showed no characteristic manifestations, need to be clear by pathological and immunohistochemical methods, the cytoplasm often expressed neuron-specific enolase, synaptophysin or chromaffin protein. Conclusion The disease is a rare malignant tumor, easily misdiagnosed, histopathological and immunohistochemical diagnosis of the disease is of great value, combined surgery and chemotherapy can improve survival.