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目的：探讨无抽搐电休克（MECT）合并利培酮、碳酸锂与单纯药物治疗双相躁狂在起效时间、疗效及住院天数、治疗费用方面的差异。方法：将60例双相躁狂患者随机分为研究组30例和对照组30例，分别予MECT合并利培酮、碳酸锂治疗及单纯利培酮、碳酸锂治疗。疗效评定依据简明精神病评定量表（BPRS）、贝克躁狂量表（BRMS）评分。结果：研究组和对照组治疗前BPRS和BRMS评分差异无显著性（P均＞0.05）；两组BRMS评分于治疗后2、3周差异有显著性（P<0.01）；两组不同时点分别与治疗前比较，均有显著性差异（P<0.01）。研究组平均住院35.0天，对照组平均住院50.2天，两组比较有显著性差异（P<0.01）；研究组平均治疗费7500.90元，对照组平均治疗费1200.30元，两组比较有显著性差异（P0.05),but significant differences were found after 2 3weeks of treatment(P<0.01);significant differences were found of the two groups scores of BPRS and BRMS atdifferent times compared with those before treatment(P<0.01).The average hospital days of sdudy group were 32.0 days and those of control group were 50.2 days, the difference was significant(P<0.01). The average treatment expense of sdudy group was7500.90yuan and that of control group was 12000.30 yuan, the difference was significant(P<0.01). Conclusion MECT Combined with Risperidone Lithium carbonate Therapy is a effective fast safe and economical method in treatment of Bipolar mania.