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目的探讨肝缺血再灌注损伤时中性粒细胞（ＰＭＮ）的聚集及川芎嗪的保护作用．方法应用家兔肝缺血再灌注损伤模型，观察肝缺血再灌注损伤过程中ＰＭＮ的浸润、脂质过氧化物（ＬＰＯ）、肝细胞形态学变化及川芎嗪的防护效应．结果随着肝缺血再灌注时间的延长，肝组织中ＰＭＮ浸润程度逐渐加重，肝细胞形态学异常变化越发显著，川芎嗪可明显减轻上述的异常变化．结论中性粒细胞聚集、粘附、活化是肝缺血再灌注损伤的重要原因，川芎嗪通过抑制ＰＭＮ聚集、粘附、活化而减轻肝缺血再灌注损伤．
Objective To investigate the accumulation of neutrophils (PMN) and the protective effect of ligustrazine on hepatic ischemia-reperfusion injury. Methods Liver ischemia-reperfusion injury model was used in rabbits to observe the infiltration of PMN, lipid peroxides (LPO), morphological changes of liver cells and the protective effect of ligustrazine during hepatic ischemia-reperfusion injury. Results With the extension of ischemia-reperfusion time, the degree of PMN infiltration in liver tissue gradually increased, and the abnormal morphological changes of hepatocytes became more pronounced. Ligustrazine could obviously reduce the above abnormal changes. CONCLUSION: Neutrophil aggregation, adhesion and activation are important factors of hepatic ischemia-reperfusion injury. Tetramethylpyrazine can reduce hepatic ischemia-reperfusion injury by inhibiting PMN aggregation, adhesion and activation.