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环己酮是一种广泛使用在PVC医疗器械生产中的粘接剂,残留的环己酮会通过输液或介入治疗等过程进入人体而产生潜在危害,快速检测残留环己酮对PVC医疗器械的质量控制具有重要意义.结合三重四极杆质谱和电喷雾萃取电离技术,建成能够对痕量环己酮气体快速检测的电喷雾萃取电离-三重四极杆质谱仪(EESI-MS/MS).通过对EESI电离源的喷雾电压、载气流速等条件进行优化,得到最优喷雾电压为3000 V,最佳载气流速为11.67 L/min,装置响应时间小于2.5 s,信号强度的相对标准偏差为4.83%,仪器的检出限为237.1×10-9(V/V).利用EESI-MS/MS实现了对PVC输液管中残留环己酮的快速检测,配合串级质谱的子离子扫描功能实现了环己酮的准确定性,同时计算得到PVC输液管中残留环己酮的浓度为362.6×10-9(V/V).建立的EESI-MS/MS在PVC医疗器械质量控制方面具有重要的应用价值.
Cyclohexanone is a widely used adhesive in the manufacture of PVC medical devices. Residual cyclohexanone can enter the human body through infusion or interventional treatment and cause potential harm. Rapid detection of residual cyclohexanone can improve the performance of PVC medical devices Quality control is of great importance.An electrospray ionization-triple quadrupole mass spectrometer (EESI-MS / MS) capable of rapid detection of trace amounts of cyclohexanone gas is established by triple quadrupole mass spectrometry and electrospray ionization ionization. By optimizing the spray voltage and carrier gas velocity of EESI ionization source, the optimal standard voltage is 3000 V, the optimal carrier gas flow rate is 11.67 L / min and the response time is less than 2.5 s. The relative standard deviation of signal intensity Was 4.83%, and the detection limit of the instrument was 237.1 × 10-9 (V / V). Rapid detection of residual cyclohexanone in PVC infusion tube was achieved by EESI-MS / MS. Function was used to determine the accurate characterization of cyclohexanone, and the residual concentration of cyclohexanone in PVC infusion tube was calculated to be 362.6 × 10-9 (V / V). The established EESI-MS / MS has the following advantages in the quality control of PVC medical devices: Important application value.