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为探讨张锡纯所拟寿胎丸的抗畸胎作用机理，笔者用昆明种小鼠给予寿胎丸煎液灌胃５天后，腹腔注射环磷酰胺，２４小时后处死取脾脏制成细胞悬液，采用ＤＮＡ解旋荧光法（Ｆｌｕｏｒｅｓ－ｃｅｎｃｅＡｎａｌｙｓｉｓｏｆＤＮＡＵｎｗｉｎｄｉｎｇ，ＦＡＤＵ）测定计算出其双链ＤＮＡ剩余率，与生理盐水灌胃５天后腹腔注射环磷酰胺组小鼠相比较，结果说明寿胎丸对环磷酰胺诱发小鼠脾细胞ＤＮＡ损伤具有极明显的防护作用。
In order to investigate the anti-tertiary mechanism of the proposed ShouTaiWan by Zhang Xichun, the author used Kunming mice to give ShouTaiWan decoction to the stomach for 5 days and then injected cyclophosphamide intraperitoneally. After 24 hours, the spleen was killed and the cell suspension was made. The DNA double-stranded DNA remaining rate was calculated by Fluores-cence Analysis of DNA Unwinding (FADU) and compared with the mice injected intraperitoneal with cyclophosphamide after intragastric administration for 5 days. The results showed that ShouTaiWan had cyclophosphamide. Induced DNA damage of mouse spleen cells has a very significant protective effect.