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①目的 探讨肿瘤坏死因子α(TNF α)和可溶性白细胞介素 2受体 (sIL 2R)与急性白血病的关系。②方法 用双抗夹心ELISA方法 ,检测 78例急性白血病病人发病期和缓解期血清TNF α和sIL 2R水平 ,并与 43例健康献血员进行比较。③结果 ANLL和ALL病人血清TNF α和sIL 2R水平均较正常对照组显著升高 (F =4.93,5 .2 5 ,q =3 .0 2～ 4.34,P <0 .0 1) ,急性白血病病人缓解前和缓解后的TNF α和sIL 2R测定结果有明显差异(F =3 .98,4.5 2 ,q =5 .16～ 6 .0 7,P <0 .0 1)。 ④结论 监测急性白血病病人血清TNF α和sIL 2R有助于急性白血病的诊断及疗效评定
Objective To investigate the relationship between tumor necrosis factor α (TNF α) and soluble interleukin 2 receptor (sIL 2R) and acute leukemia. Methods The levels of serum TNFα and sIL 2R in 78 patients with acute leukemia at the onset and remission stage were detected by double-antibody sandwich ELISA and compared with 43 healthy blood donors. 3 Results Serum levels of TNF α and sIL 2R in patients with ANLL and ALL were significantly higher than those in normal controls (F = 4.93, 5.25, q = 3.02 to 4.34, P < 0.01). Acute leukemia There was a significant difference between the TNFα and sIL 2R measurements before and after remission (F = 3.98, 4.5 2 , q = 5.16-6. 0 7, P <0.01). 4 Conclusion Monitoring serum TNFα and sIL 2R in acute leukemia patients can help diagnose and assess the efficacy of acute leukemia