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本文研究了~(152)Eu在体内选择性蓄积部位所诱发的染色体畸变效应。发现无论摄入低或高放射性活度的~(152)后,均以在骨组织中的滞留量为最高,其后依次为肾、肝、肺和血液。呈高度选择性蓄积于骨组织中的~(152)Eu,可诱发骨髓细胞染色体畸变,其畸变率随着摄入~(152)Eu放射性活度的加大而相应增升。观察到在一个骨髓细胞中同时有两个以上畸变发生,~(152)Eu可诱发的染色体结构异常为染色单体型畸变,其中主要为染色单体断裂。
In this paper, we investigated the chromosomal aberrations induced by ~ (152) Eu selective deposition in vivo. It was found that the retention in bone tissue was the highest with ~ (152) low or high radioactivity, followed by kidney, liver, lung and blood, respectively. The highly selective accumulation of ~ (152) Eu in bone tissue can induce chromosomal aberrations in bone marrow cells with a corresponding increase in the radioactivity of ~ (152) Eu. It was observed that more than two aberrations occurred in one bone marrow cell at the same time. The chromosomal structural abnormalities induced by ~ (152) Eu were the chromatid aberrations, which were mainly the chromatid breaks.