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三、其他正性收缩能药物。 1.毗丁醇(Pirbuterol):是一种新型拟交感神经胺药物,动物实验显示此药具有β_2及β_1肾上腺素能作用。口服用量20毫克或0.4毫克/公斤。文献报告表明,口服Pirbuterol一次后可使减弱的左心室功能得到持久(持续五小时)和明显的改善,心排出量增加,左室射血分数增加,平均肺动脉压下降,总体循环阻力下降。本药一般无加剧心绞痛与增加室性心律不齐的作用,仅有轻度的血管扩张作用。在已洋地黄化的心力衰竭患者,Pirbuterol有进一步增强左心室功能的作用,其机制可能为增强心肌收缩力和扩张血管二者的联合。Pributerol降低体循环血管阻力可能由于通过β_2受体直接扩张末
Third, other positive systolic drugs. 1. Pirbuterol (Pirbuterol): is a new sympathomimetic drugs, animal experiments show that the drug has β 2 and β 1 adrenergic effects. Oral dosage of 20 mg or 0.4 mg / kg. Literature reports show that once oral Pirbuterol can make the weakened left ventricular function was sustained (for five hours) and significantly improved cardiac output increased, increased left ventricular ejection fraction, mean pulmonary arterial pressure decreased, the overall resistance to circulation decreased. The drug generally does not aggravate angina and increase the role of ventricular arrhythmia, only mild vasodilatation. Pneumoputerol has the potential to further enhance left ventricular function in patients with heart-yellowed heart failure, possibly through a combination of increased myocardial contractility and dilation of blood vessels. Pributerol to reduce systemic vascular resistance may be due to direct expansion through the beta 2 receptor end