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目的:研究高血压脑出血外科治疗中重组链激酶的局部应用。方法:采用小骨窗血肿部分清除术辅以重组链激酶(r-SK)溶化引流残余血肿,治疗高血压脑出血(HICH)65例。结果:近期疗效,优良44例(67.7%),死亡8例(12.3%);随访54例,远期疗效,优良36例(66.7%),死亡2例(3.7%)。局部应用15mg的r-SK,4d内可使血肿平均减少15.6ml,加速血肿的溶化吸收。结论:研究表明小骨窗血肿部分清除术结合r-SK溶化引流残余血肿具有较好的疗效,r-SK在HICH脑内局部溶血肿作用安全高效。
Objective: To study the topical application of recombinant streptokinase in the surgical treatment of hypertensive intracerebral hemorrhage. Methods: 65 cases of hypertensive intracerebral hemorrhage (HICH) were treated with partial removal of small bone window hematoma supplemented with r-SK dissolved and drained residual hematoma. Results: The short-term curative effect was excellent in 44 cases (67.7%) and death in 8 cases (12.3%). Follow-up was performed in 54 cases. Long-term curative effect was excellent in 36 cases (66.7%) and death in 2 cases (3.7%). Topical application of 15mg of r-SK, 4d can reduce the average hematoma 15.6ml, accelerate the dissolution and absorption of hematoma. Conclusion: The results show that the partial removal of the small bone window hematoma with r-SK melt drainage residual hematoma has a good effect, r-SK in HICH intracerebral hemolysis is safe and efficient.