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目的探讨卡泊芬净治疗心脏体外循环术后重症真菌感染的安全性及有效性。方法对我院从2006年10月~2014年10月27例心脏体外循环术后侵袭性真菌感染进行回顾性分析，2010年以前13例用两性霉素B或氟康唑治疗(对照组)，2010年以后14例用卡泊芬净治疗(观察组)，治疗开始1w和2w后分别检测肝肾功能指标，疗程结束7~14d后观察治疗效果。结果治疗1~2w两组患者肝、肾功能比较，观察组明显优于对照组(<0.05),随访7~14d，观察组临床治愈率明显高于对照组(<0.035)。结论卡泊芬净是一种治疗心脏体外循环术后侵袭性真菌感染的理想药物。“,”Objective To evaluate the ef icacy and safety of Caspofungin for treatment of invasive fungous infection(IFI)in post cardiac extracorporeal circulation surgery patients.Methods Clinical data of 27 cases of cardiac extracorporeal circulation surgery patients with fungal infections were reviewed retrospectively,in13 cases fungal infections were treated with amphotericin B or Fluconazole,after 2006,the infecion was treated with Caspofungin (observation group)in 14cases.liver function and renal function were evaluated at one and two weeks espectively.Result of treatment was evaluated 7~14d after the treatment as for the clinical cure rate.Ressults 1~2 weeks treatment compared two groups with liver and kidney function,the observation group was bet er than control group ( <0.05),fol owed up for 7 to 14 d,clinical cure rate observation group was obviously higher than that of control group ( <0.035).Conclusion Caspofungin is an ideal alternative therapy for invasive fungal infection after cardiac extracorporeal circulation surgery.