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随访118例多发性肌炎病例,诊断指标为:肌无力,肌痛和触压痛,肌活检呈血管周围炎症细胞浸润或伴肌纤维变性,肌电图呈自发性活动或肌病变化,及血清肌酸激酶(CK)活性增高。全组病例女69例,男49例,比率1.4:1。发病多在成年期,62％超过40岁,仅18％小于21岁。症状主要是下肢或上肢无力,近端为重,两肩胛带和臂部疼痛,部分有吞咽困难。4％可由肋间肌无力引起呼吸困准。此外尚可有颈肌无力,眼睑下垂,肢端动脉痉挛和关节症状等。发病期无一例有心脏病症状或体征,但发病期和随访期检查的病例中心电图异常占37％,10％于随访期出现充血性心力衰竭和胸痛,而有心脏症状的60％确定为胶原血管病。
A total of 118 cases of polymyositis were followed up. The diagnostic criteria were: muscle weakness, myalgia and tenderness. Muscle biopsy showed perivascular inflammatory cell infiltration or myofibrosis. Electromyogram showed spontaneous or myopathy changes. Acid kinase (CK) activity increased. The whole group of female patients 69 cases, 49 males, the ratio of 1.4: 1. More incidence in adulthood, 62% over 40 years old, only 18% less than 21 years old. The main symptoms are weakness in the lower extremities or upper extremities, severe proximal end, pain in the shoulder blades and arm, and difficulty in swallowing. 4% by intercostal muscle weakness caused by breathing difficulties. In addition there may still be weakness of the neck, ptosis, extremity arterial spasm and joint symptoms. None of the patients had any signs or symptoms of heart disease at onset, but the electrocardiographic abnormality was found in 37% of cases during the onset and follow-up periods, with congestive heart failure and chest pain at 10% of follow-up periods and 60% of cardiac symptoms as collagen Vascular disease.