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曲地酸(asterric acid)及其类似物是从一些曲霉和青霉等真菌的发酵液中提取分离得到的一类含二苯醚结构的化合物,具有抗菌、抗肿瘤等医药活性以及杀菌、杀线虫及抑制水芹种子萌芽等农药活性,其中曲地酸作为血管内皮生长因子(VEGF)抑制剂和抗生素已被制成为商品化的生物试剂,应用于生物和医学相关领域的研究。对曲地酸及其类似物的来源、结构及物理性质、生物合成及代谢机理,以及其医用和农用活性方面的研究进展进行了综述,对其化学合成及结构改造的前景进行了展望。
Asteric acid and its analogues are a class of compounds containing diphenylether structure extracted from fermentation broths of fungi such as Aspergillus or Penicillium and have antibacterial and antitumor activities as well as sterilization, Nematodes, and the inhibition of seed germination of cress seeds. Quercetin, as a vascular endothelial growth factor (VEGF) inhibitor and antibiotic, has been made into a commercial biologic reagent and applied to research in the field of biology and medicine. The research progress on the origin, structure and physical properties, biosynthesis and metabolism of song acid and its analogues, as well as its medical and agricultural activities are summarized. The prospect of its synthesis and structural transformation is also forecasted.